The project team at UC Davis has a long track record of successful interdisciplinary research. The project is directed by Dr. Thomas Young, Professor of Civil and Environmental Engineering at UC Davis. Project co-leaders include Prof. Deborah Bennett (Professor, Public Health Sciences), Dr. Michael Denison (Professor, Environmental Toxicology), and Dr. Bruce Hammock (Distinguished Professor of Entomology and UC Davis Comprehensive Cancer Center).
Thomas Young, PI. Dr. Young has managed over $11M of grant funding as principal investigator, and he will direct all aspects of this project. In addition to his overall direction of the project, Dr. Young’s lab will conduct all of the water sample extraction, sample concentration and HRMS data acquisition. This includes supervising the staff members who will conduct extraction and concentration (Wong) and instrumental acquisition (Alaimo), and the postdoctoral scholar (Black) who will perform the bulk of the data analysis for nontarget chemical identification.
Deborah Bennett, Co-PI. Dr. Bennett will manage all aspects of participant recruitment and related activities and will provide input and guidance regarding exposure assessment and communication with the stakeholder community. Dr. Bennett has managed numerous public health studies with household volunteer involvement and is familiar with all aspects of IRB and human subjects protocols. She will manage the project work by Ms. Shira related to participant enrollment and communications.
Michael Denison, Co-PI. Dr. Denison will direct all aspects of the bioassays determining the presence of estrogenic chemicals in water extracts. Dr. Denison’s laboratory developed the estrogen receptor (ER)-cell bioassay to be used in this study, and he has more than 20 years of experience with these specific bioassay methodologies and their application to environmental, biological and chemical analysis. He will supervise the bioassay work performed by Dr. He.
Bruce Hammock, Co-PI. Dr. Hammock will oversee the advanced chemical analysis efforts performed after nontarget chemicals of interest are selected for further study when those chemicals cannot be identified using established workflows. He will also bring substantial knowledge and experience regarding cancer mechanisms and the characteristics of carcinogens to the project team. He will work with Drs. Yang and Young on the IM-HRMS data interpretation.
Daniel Tancredi. Dr. Tancredi will provide biostatistical expertise to the project, primarily during the study design and participant recruitment efforts and the data analysis stage.
Jun Yang. Dr. Yang brings extensive experience with the mass spectrometry of xenobiotic chemicals to the project. He will directly supervise the postdoctoral scholar on the IM-HRMS analysis and data interpretation.
Guochen He, Assistant Project Scientist. Dr. He will conduct the hands-on analysis of water sample extracts for estrogenic and AhR active chemicals using the AhR- and ER-cell bioassays. She has extensive background and expertise in analytical chemistry and she has more than 10 years of experience using the recombinant AhR- and ER-responsive cell lines for the analysis of extracts from a wide variety of environmental matrices, and their use in the identification of bioactive chemicals using bioassay-based fractionation approaches.
Gabrielle Black, Post-Doctoral Researcher. Dr. Black will perform the hands-on analysis of water sample extracts and non-targeted chemical analysis using HRMS data. She has 5 years of experience in analytical chemistry performing suspect and non-targeted chemical analysis in complex environmental samples. Dr. Black will combine non-targeted chemical analysis with the AhR and ER-cell bioassay data to investigate chemical features correlated with bioactivity.